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Oct 26, 2015 ... Lower core body temperature and greater body fat are components of a human ... age, sex, race, ambient temperature and whole body FFM as covariates. ... to dietary extremes through its insulating properties remains to be established. ... Schoffelen PFM, van Steenhoven AA, van Marken Lichtenbelt WD. US National Library of Medicine Search databaseSearch termSearch Journal ListHHS Author ManuscriptsPMC6417875 Int J Obes (Lond). Author manuscript; available in PMC 2019 Mar 14. Published in final edited form as: Int J Obes (Lond). 2016 May; 40(5): 754–760. Published online 2015 Oct 26. doi: 10.1038/ijo.2015.229 Lower core body temperature and greater body fat are components of a human thrifty phenotype M Reinhardt,1,2 M Schlögl,1,3 S Bonfiglio,1 SB Votruba,1 J Krakoff,1 and MS Thearle1 The publisher's final edited version of this article is available at Int J Obes (Lond) See other articles in PMC that cite the published article. In small studies, a thrifty human phenotype, defined by a greater 24-hour energy expenditure (EE) decrease with fasting, is associated with less weight loss during caloric restriction. In rodents, models of diet-induced obesity often have a phenotype including a reduced EE and decreased core body temperature. We assessed whether a thrifty human phenotype associates with differences in core body temperature or body composition. Data for this cross-sectional analysis were obtained from 77 individuals participating in one of two normal physiology studies while housed on our clinical research unit. Twenty-four-hour EE using a whole-room indirect calorimeter and 24-h core body temperature were measured during 24 h each of fasting and 200% overfeeding with a diet consisting of 50% carbohydrates, 20% protein and 30% fat. Body composition was measured by dual X-ray absorptiometry. To account for the effects of body size on EE, changes in EE were expressed as a percentage change from 24-hour EE (%EE) during energy balance.
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