Assessment and Treatment of Neuropathic Pain

https://www.practicalpainmanagement.com/pain/neuropathic/...neuropathy/ assessment-treatment-neuropathic-pain
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Nov 4, 2013 ... Physical examination for neuropathic pain includes evaluation of sensation ( including provoked pain), motor function, and autonomic changes. phantomjs://platform/webpage.js:286 in _onPageOpenFinished phantomjs://platform/webpage.js:286 in _onPageOpenFinished Home » Types of Pain » Neuropathic Pain » Diabetic Neuropathy 11 Articles in Volume 13, Issue #8 Assessment and Treatment of Neuropathic Pain Assessment of neuropathic pain begins with a thorough neurologic history, addressing the nature and onset of pain symptoms and underlying etiologic factors. Such factors include diabetes, alcohol abuse, vitamin deficiencies, environmental neurotoxins, trauma, structural lesions such as herniated nucleus pulposus or carpal tunnel syndrome, and inheritable causes. By Leo A. Lombardo, MD and Mark Wallace, MD Pain can be categorized into four mechanistic types: nociceptive, inflammatory, functional, and neuropathic.1 Nociceptive pain, a transient response to a noxious stimulus, performs a protective function to prevent tissue injury. Inflammatory pain, in which tissue damage causes both spontaneous pain and hypersensitivity, also has a protective function that may prevent further insults to an area of injury. In contrast, functional pain and neuropathic pain are maladaptive types of pain that are not a response to noxious stimuli or tissue injury. In functional pain, there is hypersensitivity due to abnormal central nervous system processing of normal peripheral sensory input. In neuropathic pain, the etiology is a lesion in the nervous system. The article will focus on the diagnosis and treatment of neuropathic pain.




Convolutional Neural Networks for Neonatal Pain Assessment ...

https://ieeexplore.ieee.org/abstract/document/8723168
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May 27, 2019 ... Abstract: The current standard for assessing neonatal pain is discontinuous and inconsistent because it depends highly on the observers bias. Journals & Magazines >IEEE Transactions on Biometri... >Volume: 1 Issue: 3 Convolutional Neural Networks for Neonatal Pain Assessment Ghada Zamzmi; Rahul Paul; Md. Sirajus Salekin; Dmitry Goldgof; Rangachar Kasturi; Thao Ho; Yu Sun Abstract:The current standard for assessing neonatal pain is discontinuous and inconsistent because it depends highly on the observers bias. These drawbacks can result in delayed ...View more For several decades, pediatricians used to believe that neonates do not feel or remember pain [1]. In 1987, the American Academy of Pediatrics (AAP) recognized neonates’ sense of pain [1]. Since then many studies (e.g., [2], [3]) reported a strong association between repeated pain exposure (under-treatment) and alterations in the structure and function of the brain. This association has led to the increased use of anesthetic medications such as Morphine and Fentanyl. However, recent studies found that the excessive use (over-treatment) of analgesic medications can cause many side effects [2], [3]. Examples of these effects include a significant increase of feeding intolerance and hypotension. The current standard for assessing neonatal pain is discontinuous and suffers from the intra- and inter-observer variations, which can lead to over- or under-treatment. Therefore, developing intelligent systems that generate continuous and less subjective pain assessment is important to mitigate the shortcomings of the current standard and improve neonatal health care.



Tools for Assessing Neuropathic Pain

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661248/
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Apr 7, 2009 ... Neurological examination in suspected neuropathic pain should include assessment of motor, sensory, and autonomic phenomena in order to ... US National Library of Medicine Search databaseSearch termSearch Journal ListPLoS Medv.6(4); 2009 AprPMC2661248 PLoS Med. 2009 Apr; 6(4): e1000045. Published online 2009 Apr 7. doi: 10.1371/journal.pmed.1000045 Tools for Assessing Neuropathic Pain Giorgio Cruccu 1 , 2 , * and Andrea Truini 1 , 2 See "A Novel Tool for the Assessment of Pain: Validation in Low Back Pain", e1000047. This article has been cited by other articles in PMC. According to the latest definition, the term neuropathic pain refers to pain arising as a direct consequence of a lesion or disease affecting the somatosensory system [1]. When physicians and researchers use the term assessment of neuropathic pain, they may be referring to two distinct types of assessment: (1) assessing pain intensity and quality and possibly their treatment-induced changes, and (2) diagnosing neuropathic (as opposed to non-neuropathic) pain. Pain is a complex experience that depends strongly on cognitive, emotional, and educational influences. Hence the pressing need for tools that can measure pain objectively. We distinguish four different levels of “objectivity”: (1) laboratory tests that use quantitative tools and measure an objective response; (2) quantitative sensory testing, a measure that despite using quantitative, graded stimuli inevitably relies on the patient's evaluation; (3) bedside examination, which relies on the physician's experience and the patient's ability and willingness to collaborate; and (4) pain questionnaires, tools that depend entirely on the patient. We review each of these in turn, drawing in part on our previous work in this field [2].



A deep neural network to assess spontaneous pain from mouse ...

https://pubmed.ncbi.nlm.nih.gov/29546805/
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Grimace scales quantify characteristic facial expressions associated with spontaneous pain in rodents and other mammals. However, these scales have not ... COVID-19 is an emerging, rapidly evolving situation. National Institutes of HealthNational Library of MedicineNCBI homepageLog in Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation . Jan-Dec 2018;14:1744806918763658. doi: 10.1177/1744806918763658. A deep neural network to assess spontaneous pain from mouse facial expressions Alexander H Tuttle  1 , Mark J Molinaro  1 , Jasmine F Jethwa  1 , Susana G Sotocinal  2 , Juan C Prieto  3 , Martin A Styner  3 , Jeffrey S Mogil  2 , Mark J Zylka  1 Grimace scales quantify characteristic facial expressions associated with spontaneous pain in rodents and other mammals. However, these scales have not been widely adopted largely because of the time and effort required for highly trained humans to manually score the images. Convoluted neural networks were recently developed that distinguish individual humans and objects in images. Here, we trained one of these networks, the InceptionV3 convolutional neural net, with a large set of human-scored mouse images. Output consists of a binary pain/no-pain assessment and a confidence score. Our automated Mouse Grimace Scale integrates these two outputs and is highly accurate (94%) at assessing the presence of pain in mice across different experimental assays. In addition, we used a novel set of "pain" and "no pain" images to show that automated Mouse Grimace Scale scores are highly correlated with human scores (Pearson's r = 0.75). Moreover, the automated Mouse Grimace Scale classified a greater proportion of images as "pain" following laparotomy surgery when compared to animals receiving a sham surgery or a post-surgical analgesic. Together, these findings suggest that the automated Mouse Grimace Scale can eliminate the need for tedious human scoring of images and provide an objective and rapid way to quantify spontaneous pain and pain relief in mice.




Neuropathic Pain - Physiopedia ***** Assessment. Screening questionnaires are suitable for identifying potential patients with neuropathic pain, but further validation of them is needed for ...

https://www.physio-pedia.com/Neuropathic_Pain

Assessment. Screening questionnaires are suitable for identifying potential
patients with neuropathic pain, but further validation of them is needed for ...




Neuropathic pain ***** Feb 16, 2017 ... The most common tools are listed below. Leeds Assessment of Neuropathic Symptoms and Signs*. Four symptom items (pricking, tingling, pins ...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5371025/

Feb 16, 2017 ... The most common tools are listed below. Leeds Assessment of Neuropathic
Symptoms and Signs*. Four symptom items (pricking, tingling, pins ...




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