Glial cell line-derived neurotrophic factor receptor alpha1 availability ...

https://pubmed.ncbi.nlm.nih.gov/10682708/
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... factor signaling: evidence from mice carrying one or two mutated alleles. Neuroscience. 2000;95(4):1011-23. doi: 10.1016/s0306-4522(99)00503-5. Public health information (CDC) Prevention and treatment information (HHS) Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation . 2000;95(4):1011-23. doi: 10.1016/s0306-4522(99)00503-5. Glial cell line-derived neurotrophic factor receptor alpha1 availability regulates glial cell line-derived neurotrophic factor signaling: evidence from mice carrying one or two mutated alleles A C Tomac  1 , A Grinberg, S P Huang, C Nosrat, Y Wang, C Borlongan, S Z Lin, Y H Chiang, L Olson, H Westphal, B J Hoffer DOI: 10.1016/s0306-4522(99)00503-5 Glial cell line-derived neurotrophic factor receptor alpha1 (GFRalpha1, also known as GDNFR-alpha) is a glycolipid-anchored membrane protein of the GFRalpha family, which binds glial cell line-derived neurotrophic factor [Jing S. et al. (1996) Cell 85, 1113-1124; Treanor J. J. et al. (1996) Nature 382, 80-83], a survival factor for several populations of central and peripheral neurons, including midbrain dopamine neurons [Lin L. F. et al. (1993) Science 260, 1130-1132], and mediates its ligand-induced cell response via a tyrosine kinase receptor called Ret [Takahashi M. et al. (1988) Oncogene 3, 571-578; Takahashi M. and Cooper G. M. (1987) Molec. Cell Biol. 7, 1378-1385]. In this paper, we show that mice with a null mutation of the GFRalpha1 gene manifest epithelial-mesenchymal interaction deficits in kidney and severe disturbances of intestinal tract development similar to those seen with glial cell line-derived neurotrophic factor or Ret null mutations. There is a marked renal dysgenesis or agenesis and the intrinsic enteric nervous system fails completely to develop. We also show that newborn GFRalpha1-deficient mice display no or minimal changes in dorsal root and sympathetic ganglia. This is in contrast to the deficits reported in these neuronal populations in glial cell line-derived neurotrophic factor and Ret null mutations. Mesencephalic dopaminergic neurons in the substantia nigra and ventral tegmental area appear intact at the time of birth of the mutated mice. Mice homozygous for the GFRalpha1 null mutation die within 24 h of birth because of uremia. Heterozygous animals, however, live to adulthood. There is a significantly reduced neuroprotective effect of glial cell line-derived neurotrophic factor in such heterozygous animals, compared with wild-type littermates, after cerebral ischemia. Taken together with previous data on glial cell line-derived neurotrophic factor and Ret, our results strongly suggest that GFRalpha1 is the essential GFRalpha receptor for signaling in the glial cell line-derived neurotrophic factor-Ret pathway in the kidney and enteric nervous system development, and that GFRalpha2 or GFRalpha3 cannot substitute for the absence of GFRalpha1. Moreover, neuroprotective actions of exogenous glial cell line-derived neurotrophic factor also require full GFRalpha1 receptor expression.



DJ Tomac – Emotions (2000, Vinyl) - Discogs

https://www.discogs.com/DJ-Tomac-Emotions/release/102076
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Jul 15, 2021 ... 2000 DJS Present / PIAS Recordings GmbH. Published by Cyclus Musikverlage Distributed by Connected. Vinyl distributed by Music Mail ... simcut, dd1, Jailer, Mrzigzac, Trepas Record Company – PIAS Germany – 556.2047.30 080 (PS) Distributed By – Connected Music Vertrieb GmbH – 5 2047 30 556 [XM] Distributed By – Music Mail Tonträger GmbH Manufactured By – Optimal Media Production – B031152 Published By – Cyclus Musikverlage Designed At – Marc Schilkowski Artwork – Bruce @ Marc Schilkowski* ℗ & © 2000 DJS Present / PIAS Recordings GmbH Published by Cyclus Musikverlage Distributed by Connected. Vinyl distributed by Music Mail Tonträger GmbH Matrix / Runout (Side A): B031152-01 A1 HL Matrix / Runout (Side B): B031152-01 B1 HL



1993 Raleigh MTi 2000 John Tomac Design - Bicycle Details ...

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Find out how much a 1993 Raleigh MTi 2000 John Tomac Design bicycle is worth. Our Value Guide is constantly growing with pricing information and bicycle ...---



Zdravko Tomac - Wikipedia

https://en.wikipedia.org/wiki/Zdravko_Tomac
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Zdravko Tomac (24 May 1937 – 4 January 2020) was a Croatian politician. ... The 2000 triumph proved to be the beginning of Tomac's political decline. From Wikipedia, the free encyclopedia Jump to navigationJump to search This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. Find sources: "Zdravko Tomac" – news · newspapers · books · scholar · JSTOR (January 2020) (Learn how and when to remove this template message) Political party League of Communists of Croatia (until 1991) Social Democratic Party of Croatia (until 2003) Zdravko Tomac (24 May 1937 – 4 January 2020) was a Croatian politician. A native of Slavonski Brod, Zdravko Tomac began his political career in the Communist Party of Yugoslavia. There he rose through the ranks, becoming a close associate of Jakov Blažević. In late 1980s he became one of the chief ideologists of the League of Communists of Croatia and one of the closest associates of Ivica Račan. After the Croatian Communist Party rebranded itself into Social Democratic Party of Croatia and lost the 1990 parliamentary elections, Tomac worked very hard to steer the party towards the nationalist course close to Franjo Tuđman and the ruling Croatian Democratic Union. Because of that, Tomac became deputy prime minister in the wartime "National Unity" government of Franjo Gregurić, thus becoming one of the first top Communist officials in Eastern Europe to return to a top executive post after the fall of the Berlin Wall. He served as deputy prime minister from August 1991 to June 1992.[1]



JOHN TOMAC AT HOME ON HIS ... - Malcolm Fearon Photography

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JOHN TOMAC AT HOME ON HIS RANCH CIRCA 2000 - Malcolm Fearon Photography. PORTFOLIO|STOCK ARCHIVE|PRINTS|ABOUT|CONTACT|CLIENTS BLISS IMAGES MTB ARCHIVE201/321






Eli Tomac - Amazon.com ***** 289-306 of over 2,000 results for "Eli Tomac" ... Eli Tomac 3 Men's and Women's Stylish and Lightweight Three-Piece Bedspread,Soft Comfy Microfiber ...

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289-306 of over 2,000 results for "Eli Tomac" ... Eli Tomac 3 Men's and Women's Stylish and Lightweight Three-Piece Bedspread,Soft Comfy Microfiber ...




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